Formulation And Evaluation Of Bi Layer Matrix Tablets

Formulation and Evaluation of Bi-Layer Matrix Tablets Containing Amoxicillin and Pantoprazole an Oral Modified Release Dosage Form for Treatment of Peptic Ulcer Sudhanshu K Chakravati1, Javed Khan Pathan1, Sapna Malviya1, Anil Kharia1 Modern Institute of Pharmaceutical Sciences, Indore (MP) ABSTRACT The aim of the present study is to formulate a dual therapy of peptic ulcer containing antimicrobial agent amoxicillin and anti-secretory agent pantoprazole, utilizing the concept of bi-layer tablet system for the effective treatment of H. pylori associated gastric/duodenal ulcer, in an attempt to improve bioavailability and to get maximum therapeutic benefits and patient compliance about the treatment. Different formulas of 575 mg amoxicillin were prepared as sustained release layer by wet granulation method and different formulas of 40 mg pantoprazole in form of immeadeaye release was prepared as extended release matrix layer by direct compression technique. The results showed that formulas prepared with Hydroxypropylmethyl cellulose (HPMC K100M) and xanthan gum and acasia as binder was capable to retard the release of Amoxicillin and Pantoprazole for 12 hr and 8hr respectably which according to dosing frequency of amoxicillin in treatment of peptic ulcer (twice daily) it will prev ent drug free interval so achieve complete eradication of H. pylori, thus it was selected for preparation of bi-layer tablet. Regarding Pantoprazole, formula PS-6 (which consist of HPMC K 15 M,Show MoreRelatedThe Human Gastrointestinal Track Is A Complex Time9513 Words   |  39 Pagesinterest in multiple-layered tablets as an oral controlled release System has increased. Multiple-layered tablets have some advantages Compared to conventional tablets. Commonly used to no chemical Incompatibilities of formulation components by physical separation. Release profiles of drug may depend on combining layers with different release patterns, and by combination of slow-release with immediate-release layers. Conte and Maggi have described an oral controlled-release tablet called Geomatrix, whichRead MoreStrategic Marketing Management337596 Words   |  1351 Pagesand the development of strategy The competitive intelligence system The development of a competitive stance: the potential for eth ical conflict Summary CONTENTS vii Stage Two: Where do we want to be? Strategic direction and strategic formulation 7 Missions and objectives 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 Learning objectives Introduction The purpose of planning Establishing the corporate mission Influences on objectives and strategy Guidelines for establishing objectives and setting goals