Formulation And Evaluation Of Bi Layer Matrix Tablets

Formulation and Evaluation of Bi-Layer Matrix Tablets Containing Amoxicillin and Pantoprazole an Oral Modified Release Dosage Form for Treatment of Peptic Ulcer Sudhanshu K Chakravati1, Javed Khan Pathan1, Sapna Malviya1, Anil Kharia1 Modern Institute of Pharmaceutical Sciences, Indore (MP) ABSTRACT The aim of the present study is to formulate a dual therapy of peptic ulcer containing antimicrobial agent amoxicillin and anti-secretory agent pantoprazole, utilizing the concept of bi-layer tablet system for the effective treatment of H. pylori associated gastric/duodenal ulcer, in an attempt to improve bioavailability and to get maximum therapeutic benefits and patient compliance about the treatment. Different formulas of 575 mg amoxicillin were prepared as sustained release layer by wet granulation method and different formulas of 40 mg pantoprazole in form of immeadeaye release was prepared as extended release matrix layer by direct compression technique. The results showed that formulas prepared with Hydroxypropylmethyl cellulose (HPMC K100M) and xanthan gum and acasia as binder was capable to retard the release of Amoxicillin and Pantoprazole for 12 hr and 8hr respectably which according to dosing frequency of amoxicillin in treatment of peptic ulcer (twice daily) it will prev ent drug free interval so achieve complete eradication of H. pylori, thus it was selected for preparation of bi-layer tablet. Regarding Pantoprazole, formula PS-6 (which consist of HPMC K 15 M,Show MoreRelatedThe Human Gastrointestinal Track Is A Complex Time9513 Words   |  39 Pagesinterest in multiple-layered tablets as an oral controlled release System has increased. Multiple-layered tablets have some advantages Compared to conventional tablets. Commonly used to no chemical Incompatibilities of formulation components by physical separation. Release profiles of drug may depend on combining layers with different release patterns, and by combination of slow-release with immediate-release layers. Conte and Maggi have described an oral controlled-release tablet called Geomatrix, whichRead MoreStrategic Marketing Management337596 Words   |  1351 Pagesand the development of strategy The competitive intelligence system The development of a competitive stance: the potential for eth ical conflict Summary CONTENTS vii Stage Two: Where do we want to be? Strategic direction and strategic formulation 7 Missions and objectives 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 Learning objectives Introduction The purpose of planning Establishing the corporate mission Influences on objectives and strategy Guidelines for establishing objectives and setting goals

Diabetes A Common And Well Known Disease - 1564 Words

Introduction Diabetes is a common and well-known disease in the US. Healthcare providers manage the care of patients daily as both direct and indirect effects of diabetes contribute to their poor health. Diabetes mellitus type 2 is characterized by high blood sugar levels as a result of insulin resistance. The risk factors associated with an increasing prevalence in the US includes genetics, family history, poor eating habits, sedentary lifestyle, and obesity.1 Healthcare providers are challenged to assess each diabetic patient’s limitations and address the issues that impact the ability to control their diabetes. Treatment adherence is a constant issue in the management of patients. In primary care settings, it is not uncommon for the providers to observe a significant percentage of poor compliance to treatment plans and subsequent poor control of blood sugar measured by HgA1c within their patient population. The high prevalence of this disease in the US emphasizes the need to increase treatment adherence and promote self-management. How can providers improve their practices to achieve better rates of adherence and maximize healthy outcomes? How do we further address the multiple factors playing a role in patient outcomes? In this performance improvement plan, one physician assistant student in a primary care practice focuses on addressing patient barriers and social/situational factors during each visit to empower self-management of patients’ diabetes. Literature ReviewShow MoreRelatedDiabetes : A Common And Well Known Disease That Affects People Of Different Ages1548 Words   |  7 PagesAbstract This paper explores the three different types of Diabetes, a common and well-known disease that affects people of different ages. It explains the difference between Type 1, Type 2, and Gestational Diabetes and how prevalent it is in today’s generation. A sudden spike in a person’s blood sugar numerous times is an indication that a person has developed this disease. There are countless of people that are not fully aware of what a consistent rise in blood sugar can do to a person’s body.Read MoreDiabetes As A Western Disease1489 Words   |  6 Pagesenergy, some may make us sluggish and lazy. Diabetes has been around for decades, as the increase in assortment of food and different varieties have become assessable to individuals globally, we have been dealt with a larger problem than many predicated. Diabetes started as a western disease has made its way to being a global problem with many organizations leading the fight to find ways to reduce the epidemic. While many may disagree that the disease has reach its apex and have already spread,Read MoreDiabetes : Type 1 And Type 2 Essay1710 Words   |  7 PagesDiabetes is a disease where the body is unable to produce or use insulin effectively. Insulin is needed for proper storage and use of carbohydrates. Without it, blood sugar levels can become too high or too low, resulting in a diabetic emergency. It affects about 7.8% of the population. The incidence of diabetes is known to increase with age. It’s the leading cause of end-stage renal disease in the US, and is the primary cause of blindness and foot and leg amputation. It is known to cause neuropathyRead MoreDiabetes : A Growing Issue1149 Words   |  5 PagesDiabetes mellitus has been a growing issue in the United States. Type 2 diabetes has been in the spotlight due to the rapidly increasing numbers of obese Americans. Many people suffering from type 2 diabetes can control or overcome the disease by adopting a healthier lifesty le. Unfortunately, not all diabetics can correct or prevent the problem with better diet and exercise. Type 1 diabetes can affect anyone; including people with a healthy lifestyle. At this time, there is no known cure for TypeRead MoreDiabetes : Diabetes And Type Two Diabetes1688 Words   |  7 Pagesglucose levels results in the disease that is broken down into two main types, type one diabetes and type two diabetes. Type one diabetes is an autoimmune disease, meaning a disease in which the body s immune system attacks healthy cells, that causes the insulin producing beta cells in the pancreas to be destroyed. The immune system, by mistake, attacks its own insulin-producing cells so that insufficient amounts of insulin are produced or no insulin at all. Type one diabetes is also referred to as insulinRead MoreDiabetes Mellitus Type 2 Diabetes1628 Words   |  7 PagesDiabetes mellitus type 2, also know as type 2 Diabetes or noninsulin dependent diabetes, is a disease that effect s the body systemically. Type 2 diabetes is a disorder in which cells become resistant to insulin and can no longer bind it properly to reduce blood sugar. The result of this is elevated glucose levels in the circulating blood that leads to endothelial injury in all regions of the body. Primary damages occur in the kidneys, cardiovascular, and digestive systems. According to â€Å"Annual NumberRead MoreDiabetes : An Incurable Disease1707 Words   |  7 Pagesâ€Å"29.1 million people in the United States have diabetes, 8.1 million of whom may be undiagnosed or unaware of their condition.† (healthline.com). Diabetes is an incurable disease that is caused by unstable levels of blood sugar in the cells that could later result in heart failure, kidney diseases, or even an amputation. There are two types of diabetes, Type 1 and Type 2. The two differentiate when it comes to how the insulin itself if being effected. What is insulin? Insulin is a peptide hormoneRead MoreThe Health And Economic Consequences Of Diabetes1594 Words   |  7 Pages Diabetes affects 18.2 million people in the United States. It is often referred to by doctors as diabetes mellitus and described as, â€Å"†¦ a metabolic disease in which the person has high blood sugar †¦Ã¢â‚¬  (Collazo- Clavell et all. 2009), either because the insulin is inadequate or the body’s cells don’t respond well to the insulin. The health and economic consequences of diabetes are considerable. The majority of people that have diabetes live in low and middle income countries, where the prevalenceRead MoreDiabetes Mellitus : Type 1 Diabetes1017 Words   |  5 PagesBushaw Diabetes Mellitus: Type 1 Diabetes Research Paper 11/16/2014 Diabetes Mellitus also known as—Juvenile Onset Diabetes, Type 1 Diabetes, and Insulin Dependent Diabetes. It is a chronic autoimmune disease described by high blood glucose levels due to insulin levels being inadequate to maintain normal glucose levels. This research paper will discuss the symptoms and signs, etiology, who it triggers, how it happen, and treatment for Type 1 Diabetes. Symptoms and signs of Type 1 Diabetes are hyperglycemiaRead MoreDiabetes Mellitus : The Most Common Disorder Of The Endocrine System957 Words   |  4 PagesDiabetes Mellitus stems from the Greek word diabetes, which means to siphon, or to pass through. Mellitus is Latin for sweet or honeyed. Diabetes Mellitus is the most common disorder of the Endocrine System. The pancreas is an organ behind the stomach that produces a hormone called insulin. When this happens, our liver compensates by increasing glucose production from amino acids and glycogen causing hyperglycemia. There are different types of diabetes; however, this paper strictly focuses on Type

Myth Or Science Essay Example For Students

Myth Or Science? Essay Throughout history there have been many attempts to explain the origin and workings of our universe. Most every culture has their own cosmogony. Nearly every individual has his or her own idea of what our universe is. During our modern era of advanced scientific knowledge, we feel that we have a good grasp on how the universe works. We have our Chemistry and Physics, along with Mathematics, to examine the universe with. Any person educated in these fields will tell you that they know our universe. The point is science in the modern era is thought to be the correct summation of the universe. We think we are right. Does this make everyone else wrong? Those that believe in myth over science, are they wrong? These are some of the questions that I will be discussing in this essay. I will examine the evolution of cosmological thought in Ancient Greece (Pre-Socratics through Aristotle). In doing this, I will show a movement from myth to more science based cosmologies. I will then examine th e Buddhist Cosmology, which is somewhat separated from Ancient Greek thought. After all of this, I will examine the question of which is more correct, Science or Myth. Before continuing a clear definition of ?myth? needs to be established. The term myth has multiple meanings. Websters II Dictionary, defines it the three different ways. ?1. A traditional story that deals with supernatural beings, ancestors, or heroes that serve as primordial types in a primitive view of the world. 2. A real or fictional story that appeals to the consciousness of a people by embodying its cultural ideals or by giving expression to deep commonly felt emotions. 3. A fictitious or imaginary person, idea, or thing.? For the sake of this essay, I would like the second definition to apply to my use of the word myth. The term myth should not be thought of as fictitious or primitive. The possibility for the myth to be real should always be considered. Some of the earliest known philosophies on the creation of the Earth come from the works of Hesiod. In his Theogony he attempts to explain the creation of the Earth, and all that surrounds him, using myth. In the myth Hesiod an thropomorphizes the cosmos. He tells of ?Chaos? being the first to come into being, then he goes on to describe how each of the gods of the cosmos comes in to being. The gods of the cosmos are all related to some characteristic of our universe. They can be physical parts or concepts (similar to Platos idea of the forms). For example the line, ?Earth first bore starry Heaven, equal to herself, to cover her on every side, and to be an ever-sure abiding-place for the blessed gods.?(Theogony, 126) describes both the act of birth, which is a human characteristic, and physical parts of the universe being gods (Heaven meaning the stars, and the Earth). He also has gods, such as Eros, which represents the concept of Love. Two main issues the come up during discussions of cosmology are how the universe was created and out of what was the universe created. In the Theogony, Hesiod has the world created out of gods that are human by nature and to create this universe the gods reproduced. Hesiods theories of the universe can clearly be classified as myth, since there is no scientific background for it. The philosophers to follow Hesiod moved slightly away from this. The Pre-Socratics begin to de-anthropomorphize the universe. Even later, in the works of Socrates and Plato, the universe is completely de-anthropomorphized. The Pre-Socratics focus more on what the universe was made of than how it was created. They typically chose a single element that everything consisted of and tried to explain the world according to that element. Sometimes these elements were one of the basic four elements; earth, fire, air, and water. Sometimes they were more abstract such as Anaximanders theory. ?The principle element of existing things was the aperion it is neither water nor any other of the so-call elements, but some other aperion nature, from which come into being all the heavens and the worlds in them.?(Hetherington, pg. 58) The Pre-Socratics based their theories on insight and observations. For this reason their theories are both mythical and scientific. Because some of their choices of what the key element is are based on instinctive feelings, they can be considered myth. On the other hand, they support their ideas through observations and experience making the ideas scientific. Science is defined one way in Websters II Dictionary to be ?Knowledge that is acquired through experience.? The Pre-Socratics were not completely scientific because not everything they theorized was based on experience, but they were not as mythical as Hesiod either. Diabetes EssayMultiple lives, reincarnation, is another important aspect of the Buddhist thought. The idea of karma plays a major role in the lives of Buddhists. ?In Buddhism, an individual experiences rebirth into this world and begins the volitional production of both good and bad karma, or lay, which will determine his or her future rebirth and chances for enlightenment.? (French, pg. 63) To reach enlightenment is the highest standard for the Buddhists, which might be why nirv?na is placed on the outer most edge of their world. To reach enlightenment one must have developed a high level of good karma. Those that do not reach enlightenment in their lifetime are reborn into the world, and the life given to them is based on the level of karma they were at when they died. This makes karma not only important because it is the way to reach enlightenment, but also because it will provide a better life. After discussing the cosmogonies of different cultures, we have come across to different methods of thought. These being, myth and science. We have seen the Greek thought move from myth to science, and we have seen the Buddhist thought focus in on myth. The question arises, which method of thought is better or more accurate? Ask an astronomer or a physicist, and they will probably tell you that science is more accurate. Ask a Buddhist monk or a Zen master and they might tell you that myth is better (if the definition of myth is presented to them properly). The physicist will argue that science has evolved so far that we can accurately predict the motion of the planets, we can explain the process of recreation, etc. This is a very strong argument for using science to explain the universe. The Buddhist monk will reply that we only believe that we know those things and that it is just a part of the illusion of the first reality. This wont convince the physicist, but it does open another door. A person who opens their minds to all the possibilities will not be able to rule out the idea that everything we perceive could simply be an illusion presented to us. Science itself could be the illusion. If the entity that set up the illusion (if there is one) wanted the illusion to be believable, they most likely would place a set of laws on the illusion to keep it consistent. These laws could be the laws that we are now discovering and calling science. This is just one of many possible arguments for myth being the method of explanation of the universe. A scientist might not agree and say that this argument is implausible, but their only evidence against it would be the science that has been declared illusionary. By no means am I stating that myth is the proper method of explaining the universe. I am merely stating that it, and science, are possible explanations. Which one to believe in is complete up to the individual. Bibliography:Hetherington, Norriss S. Cosmology : Historical, Literary, Philosophical, Religious, and Scientific Perspectives. New York ; London: Garland Publishing, Inc, 1993. French, Rebecca Redwood. The Golden Yolk : The Legal Cosmology of Buddhist Tibet. Ithaca ; London, Cornell University Press, 1995. Kloetzli, Randy. Buddhist Cosmology. Delhi, Motilal Banarsidass, 1983.

Pan American World Airways, Inc Essays - Pan American World Airways

Pan American World Airways, Inc Pan American World Airways, Inc ("Pan Am") is a New York corporation organized in 1927 which is engaged in commercial air transportation which it pioneered between the United States and most areas of the world. Pan Am Corporation ("the Corporation"), a Delaware corporation, is and since September 14, 1984 has been the parent of Pan Am, it's principal subsidiary. For the past few years Pan Am's financial condition has been very poor. The company reported a consolidated net loss for 1986 of $469.3 million. The 1988 net loss included a gain of $89.1 million resulting from the sale of Pan Am's Airbus A320 aircraft and delivery positions. This gain was partially offsetted by a reserve of $25.7 million related to the loss on sale of Pan Am's subsidiary, which is responsible for the marketing of excess inventory, and 18 million of year-end adjustments. Pan Am's passenger traffic was strong in 1988. An increase of 12.2 percent on capacity of 11.2 percent. This was due to the result of strengthening of various European currencies against the U.S. dollar, fare increases in the market, enhanced management systems and procedures, as well as programs to reduce the dependence on wholesale ticket distributions throughout the Atlantic, Latin America, Domestic, and systemwide. Eventhough revenue was strong in 1988, labor and other costs increased at a higher rate as a consequence of efforts to improve service and effectiveness of the operation. Labor costs were higher in 1988 due to the result of an increase in the number of employees during the year. Also the addition of increased fuel prices, commissions, purchased services, aircraft rentals, and a $24.0 million foreign exchange loss had a negative impact on the corporation. 1987 expenses were effected by increases in expenses for fuel, commissions, maintenance materials and other operating costs which exceeded expectations. Labor cost reductions were not achieved in 1987. Other losses which occurred was the settlement of an $18 million provision for the proposed settlement of an age discrimination suit, and as well as $42.0 million for increased allowances for inventory obsolescence, uncollected receivables and costs associated with the WorldPass frequent flyer program. COMPANY BACKGROUND Pan Am lead by it's founder Juan Trippe, virtually single- handedly opened up the world to commercial flight. Teeming with adventure, international intrigue, and financial manipulations, this sky-struck young man with immense ambition and vision took a seaplane carrying mail 90 miles from Key West to Havana and expanded the operation into the vast world-wide airline that at one time considered itself the "chosen instrument" of the State Department abroad. The airline was considered so official by Washington that Trippe had power to make deals with foreign governments abroad . In 1934 people thought it was virtually impossible to cross the Pacific by air, but Trippe saw a way to do it. Through the use of the famous Clipper Flying Boats, Trippe achieved the impossible, and started the worlds first trans-atlantic flights to europe, asia, and south america. Pan Am achieved great heights with the help of pilots like Charles Lindbergh, who opened many early routes, and hero pilot Eddie Musick, who pioneered routes across the Pacific, and not to mention Andre Priester, the engineering marvel behind the early flying boats. Currently Pam Am provides non-stop service from the states to 36 locations in europe, asia, and south america. The company strives to provide the best service to all it's destinations than all the other carriers in general. Presently the airline is trying to achieve a "Corporate Image" to attract more business people thus increasing passenger revenues. ASSESSMENT OF COMPANY'S PERFORMANCE AND FINANCIAL CONDITION Overall, the short term liquidity of Pan Am seems to have a stable trend but is very poor compared to the average industry's ratios. Through the past two years very little changes can be seen in the short-term liquidity ratios. The firm acid test ratio puts it in the lower quartile. As for capital structure and long-term solvency we can only say that the firm is experiencing heavy losses and is relying on long term loans and secured notes in order to finance themselves. A stockholder deficit and net losses gave all index ratios negative values. So again we can see that the capital structure and long-term solvency of the firm is quite poor. Return on investments where quite poor since no change occurred on the return of investment and return on equity due to the stockholder deficit. As for operating performance ratios, these figures where quite poor also due to heavy losses in operating